Complement
Now Approved icon
For adults with recurrent Clostridioides difficile (C. diff) infection

The first and only FDA-approved microbiota-based
therapeutic in oral capsules to prevent C. diff
recurrence following antibacterial treatment1

Limitation of Use: VOWST is not indicated for treatment of CDI

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VOWST HELPED PREVENT
SUBSEQUENT C. DIFF RECURRENCE

Significantly reduced C. diff recurrence at 8 weeks
compared to placebo following standard-of-care antibacterials in the ECOSPOR III clinical trial1,2

Primary endpoint - rate of recurrence was significantly lower in
VOWST recipients compared to placebo (12% vs. 40%, respectively),
a 0.32 relative risk (95% confidence interval, 0.18, 0.58; P<0.001)1,2

88%

(vs. 60% of participants
receiving placebo)1,2


Recurrence-free response through 24 weeks — secondary endpoint1,3

79%

(vs. 53% of participants
receiving placebo)1,3*

*Relative risk of 0.46 (95% CI 0.30, 0.73 for VOWST and placebo, respectively).

ECOSPOR III was a Phase 3, multicenter, double-blind, randomized, placebo-controlled trial evaluating C. diff recurrence at 8 weeks; secondary endpoints at 4, 12, 24 weeks. In the intent-to-treat population, participants received VOWST or placebo after standard-of-care antibacterial treatment (vancomycin/fidaxomicin) and laxative. Those lost to follow-up, terminated prematurely, or died prior to end of study time interval counted as a recurrence. Data were rounded to the nearest whole number for presentation.

Safety profile of VOWST through 8 weeks1

The majority of adverse reactions were mild
or moderate in severity1

The most common adverse reactions (reported in ≥5% of participants) were abdominal distension (31%), fatigue (22%), constipation (14%), chills (11%), and diarrhea (10%)1

No serious adverse events were considered related to the use of VOWST1

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Consider prescribing VOWST and antibacterials at the same time to help ensure patients get access to VOWST at the time of completing antibacterials

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Why C. diff can keep
coming back

Antibacterials can leave
patients at risk of recurrence

Learn about the burden
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Oral VOWST
dosing

4 capsules taken orally once daily over 3 consecutive days

See the step-by-step guide
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Get information about VOWST Voyage™

Helping your patients
access their VOWST treatment

How to enroll

REFERENCES: 1. VOWST [Prescribing Information]. Cambridge, MA: Seres Therapeutics, Inc. and Nestlé Health Science. 04/2023. 2. Feuerstadt P, Louie TJ, Lashner B, et al. N Engl J Med. 2022;236:220-229. doi:10.1056/NEJMoa2106516. 3. Cohen SH, Louie TJ, Sims M, et al. JAMA. Published Online: October 19, 2022. doi:10.1001/jama.2022.16476.